العربية
العملة EGP
Aripexia شراء في القاهرة
شراء Aripexia
Aripexia

Aripexia

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مصر, القاهرة
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PHARMACOLOGICAL ACTION:

Aripiprazole functions as a partial agonist at the dopamine D 2 and the serotonin 5-HT 1A receptors, and as an antagonist at serotonin 5-HT 2A receptor.. The mechanism of action of aripiprazole, as with other drugs having efficacy in schizophrenia and bipolar disorder, is unknown. However, it has been proposed that the efficacy of aripiprazole is mediated through a combination of partial agonist activity at D 2 and 5-HT 1A receptors and antagonist activity at 5-HT 2A receptors.

Pharmacokinetics:
Aripiprazole is well absorbed after administration of the tablet, with peak plasma concentrations occurring within 3 to 5 hours . Aripiprazole is metabolized primarily by three biotransformation pathways: dehydrogenation, hydroxylation, and N-dealkylation. CYP3A4 and CYP2D6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and N-dealkylation is catalyzed by CYP3A4.

INDICATIONS:
Aripexia is indicated for the treatment of schizophrenia , acute manic and mixed episodes associated with Bipolar Disorder .

DOSAGE AND DIRECTIONS FOR USE:
Schizophrenia
The recommended starting and target dose for Aripexia is 10 or 15 mg/day administered on a once-a-day schedule without regard to meals. ABILIFY has been systematically evaluated and shown to be effective in a dose range of 10 to 30 mg/day .Dosage adjustments are not routinely indicated on the basis of age, gender, race, or renal or hepatic impairment status .
Bipolar Disorder
The starting dose was 30 mg given once a day.

SIDE-EFFECTS:
gastrointestinal disorders such as constipation, dyspepsia, nausea, and vomiting, headache, anxiety, insomnia, lightheadedness, and drowsiness. Weight gain has been reported .Orthostatic hypotension may occur with aripiprazole treatment .

WARNINGS & Precautions
Aripexia should be used with caution in patients with cardiovascular or cerebrovascular disease, or in those with conditions that would predispose to hypotension.

CONTRA-INDICATIONS:
Aripexia is contraindicated in patients with a known hypersensitivity to Aripiprazole .

Drug Interactions:
Agents that induce CYP3A4 (e.g., carbamazepine) could cause an increase in aripiprazole clearance and lower blood levels. Inhibitors of CYP3A4 (e.g., ketoconazole) or CYP2D6 (e.g., quinidine, fluoxetine, or paroxetine) can inhibit aripiprazole elimination and cause increased blood levels.

PRESENTATION:
Cartoon box contain one or two (Al/Pvc) strip each strip contain 10 tablets With inner leaflet
stored In dry state at room temperature (15-30°c)

Keep out of reach of children

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Aripexia
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